Starting with McAfee VirusScan V8, Network Associates have discontinued support for the SCAN32.EXE command-line virus scanner, which means that the previously documented methods for using VPOP3 with McAfee VirusScan will no longer work.
However, VirusScan V8 now supports a transparent POP3/SMTP email virus scanner which can be used with VPOP3.
To configure this, go into the McAfee SecurityCenter (Start -> Programs -> McAfee -> McAfee SecurityCenter) and click on the VirusScan tab.

Then, click on the Configure VirusScan Options button

On the ActiveShield tab, make sure that the Scan e-mail and attachments option is checked. Then press Advanced.

Go to the E-mail Scan tab, and check that the Automatically clean infected attachments option is selected. (If you select the Prompt me when an attachment needs to be cleaned option, then the VPOP3 process may be frozen by VirusScan).
Press OK, then OK again and then close down the McAfee SecurityCenter.
Note that if you use this method, then the extra options that are included with the integrated virus scanner options (currently Sophos and avast! for VPOP3), such as informing the email sender, reporting problems to the administrator, etc, will not be available.
(Note if you are going to use this method, you should check the Licence conditions of your McAfee software to see if this type of usage is allowed under your licence conditions, and whether you may need to purchase extra licences from Network Associates)